Non-invasive In-vivo Temperature Mapping of Ultrasound Heating Using Fluorine-based Magnetic Resonance Imaging Agents
نویسندگان
چکیده
The aim of this study was to investigate the feasibility of using fluorine based magnetic resonance to measure accurately hepatic heat ing from a focused ultrasound transducer in rats. This new method uses the fluorine chemical shifts within a single temperature dependence of the difference in for complicating physiological effects. molecule to provide internal compensation Female Sprague-Dawley rats were exposed to 5 minutes of CW irradiation at 1.37 MHz f rom a focused transducer. Theoretical calculations based on the monopole source solution to the bio-heat transfer equation gave a volume-averaged temperature rise of 2.1 "C. Preliminary experiments using p r o t e i n e n c a p s u l a t e d p r f l u o r o octylbromide targeted to the liver gave an empirical rise of 2.0 f0.4 'C.
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